[Modezhel' erythrocyte preservative as an experimental and clinical blood substitute].

Abstract

The model of hemorrhagic shock in dogs was used to show that the infusion of "Modegel" normalizes the arterial pressure, substantially increases the minute volume of blood circulation. The circulating blood volume rises up to the initial level at the expense of the increased plasma volume. "Modegel" gives stable correction of the acid-base balance of blood. In clinic "Modegel" was used for filling the apparatus of artificial circulation and compared with the blood substitute "Gelatinol" for operations on the open heart. Examinations of the patients have shown that "Modegel" unlike "Gelatinol" does not induce hypercalcemia and hyperosmolarity of plasma while moderate hyperoncoticity of plasma is responsible for the circulating blood volume and favorable conditions for microcirculation.

• Authors: E A Selivanov, V N Mel'nikova, N I Kochetygov, V T Pleshakov, K A Gerbut, I M Krivtsova, G O Lur'e
• Journal: Vestnik khirurgii imeni I. I. Grekova (Vestn Khir Im I I Grek) Issue 1 Pg. 71-4 ( 1996) ISSN: 0042-4625 [Print] Russia (Federation)
• Vernacular Title: Eritrokonservant "Modezhel'" kak krovezamenitel' v éksperimente i klinike.
• PMID: 8753967 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Blood Substitutes
• Plasma Substitutes
• Gelatinol
• Gelatin

Topics

• Animals
• Blood Preservation
• Blood Substitutes (therapeutic use)
• Dogs
• Drug Evaluation
• Drug Evaluation, Preclinical
• Erythrocytes
• Gelatin (therapeutic use)
• Hemodynamics (drug effects)
• Hemostasis (drug effects)
• Humans
• Plasma Substitutes (therapeutic use)
• Shock, Hemorrhagic (blood, physiopathology, therapy)
• Time Factors