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Protective effect of cystathionine on acute gastric mucosal injury induced by ischemia-reperfusion in rats.

Abstract
We studied the protective effect of cystathionine on acute gastric mucosal injury induced by ischemia-reperfusion in rats. Under pentobarbital anesthesia, the celiac artery was clamped for 30 min and reperfused. Sixty minutes after the reperfusion, the total area of erosions and thiobarbituric acid-reactive substances in the stomach, as an index of lipid peroxidation, were measured and compared between control and cystathionine-treated groups. Intraperitoneal administration of cystathionine (1-20 mg/kg) 10 min before the ischemia significantly reduced both the total area of erosions and the level of thiobarbituric acid-reactive substances. When cystathionine (10 mg/kg) was administered orally, the significant reductions in the total area of erosions and level of thiobarbituric acid-reactive substances were also observed. There was a good correlation between the total area of erosions and the level of thiobarbituric acid-reactive substances. Cystathionine did not affect blood flow during ischemia-reperfusion. These results indicate that the protective effect of cystathionine on acute gastric mucosal injury induced by ischemia-reperfusion may be due to the scavenging action against superoxide radicals in vivo.
AuthorsK Wada, Y Kamisaki, M Kitano, K Nakamoto, T Itoh
JournalEuropean journal of pharmacology (Eur J Pharmacol) Vol. 294 Issue 2-3 Pg. 377-82 (Dec 29 1995) ISSN: 0014-2999 [Print] NETHERLANDS
PMID8750697 (Publication Type: Journal Article)
Chemical References
  • Free Radical Scavengers
  • Cystathionine
Topics
  • Animals
  • Cystathionine (pharmacology)
  • Free Radical Scavengers (pharmacology)
  • Gastric Mucosa (blood supply, drug effects, metabolism)
  • Ischemia (metabolism, pathology)
  • Lipid Peroxidation
  • Male
  • Rats
  • Rats, Wistar
  • Regional Blood Flow (drug effects)
  • Reperfusion Injury (pathology, prevention & control)

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