Abstract | OBJECTIVE: To analyze the discriminative capability of morphometric assessment of nuclear morphology in the differential diagnosis of small round blue cell tumors (SRCTs) of bone and soft tissue. STUDY DESIGN: The study material consisted of glutaraldehyde-fixed, resin-embedded, semithin sections from 119 human tumors. Nuclear area, perimeter, maximum diameter, form factors and nuclear density were measured in at least 300 nuclei per case. RESULTS: CONCLUSION: Morphometric characterization of nuclear features reveals differences between the distinct groups of SRCTs. Although overlapping occurred between all these groups at the individual case level, this study provides new support for the existence of morphologic links within the family of ES and PNET.
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Authors | R C Callaghan, C Carda, A Peydró-Olaya, T Triche, A Llombart-Bosch |
Journal | Analytical and quantitative cytology and histology
(Anal Quant Cytol Histol)
Vol. 17
Issue 6
Pg. 374-82
(Dec 1995)
United States |
PMID | 8750351
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Bone Neoplasms
(pathology)
- Cell Nucleus
(ultrastructure)
- Humans
- Neuroblastoma
(pathology)
- Neuroectodermal Tumors, Primitive, Peripheral
(pathology)
- Osteosarcoma
(pathology)
- Rhabdomyosarcoma
(pathology)
- Sarcoma
(pathology)
- Sarcoma, Ewing
(pathology)
- Soft Tissue Neoplasms
(pathology)
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