Abstract |
We have examined the effect of intratympanic gentamicin on hearing and tinnitus in 69 patients with intractable Menière's disease. Tinnitus was scored from 1 to 4 depending on its severity. The mean pure tone audiometry level before treatment was 57.5 dB and 1 year after treatment 63.5 dB Five subjects became deaf in the treated ear, and in 13 subjects hearing loss was > 10 dB and in 21 subjects 0 10 dB. In 25 subjects significant improvement (> 10 dB) was gained, and in 5 patients. Tinnitus was significantly reduced after treatment with gentamicin. A total of 66 patients had tinnitus before treatment and tinnitus relief was rated as good. Four percent of the subjects had no tinnitus, 30% had slight tinnitus. 27% moderate tinnitus. 18% severe and 8% handicapping tinnitus.
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Authors | S Kaasinen, I Pyykkö, H Ishizaki, H Aalto |
Journal | Acta oto-laryngologica. Supplementum
(Acta Otolaryngol Suppl)
Vol. 520 Pt 1
Pg. 184-5
( 1995)
ISSN: 0365-5237 [Print] Norway |
PMID | 8749114
(Publication Type: Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Gentamicins
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Topics |
- Administration, Topical
- Adult
- Aged
- Anti-Bacterial Agents
(administration & dosage, adverse effects)
- Audiometry, Pure-Tone
- Auditory Threshold
(drug effects)
- Ear, Middle
(drug effects)
- Female
- Gentamicins
(administration & dosage, adverse effects)
- Humans
- Male
- Meniere Disease
(drug therapy)
- Middle Aged
- Pitch Discrimination
(drug effects)
- Speech Perception
(drug effects)
- Tinnitus
(drug therapy)
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