Identification of a membrane-associated receptor for transforming growth factor type E.

Abstract

We have identified the receptor for epithelial type transforming growth factor (TGFe). TGFe, a member of the epithelin/granulin family of proteins, is present primarily in tissues of epithelial origin. It is a powerful mitogen for epithelial and fibroblastic cells. TGFe, iodinated using an immobilized glucose oxidase-lactoperoxidase method, was chemically crosslinked to receptors on membranes isolated from SW-13 adrenal carcinoma cells by the crosslinker disuccinimidyl suberate (DSS). The receptor appears to be a protein which migrates at an apparent molecular weight of approximately 170-175 kDa under reducing and nonreducing conditions in SDS-polyacrylamide gels.

• Authors: P G Parnell, B J Carter, J Halper
• Journal: Journal of receptor and signal transduction research (J Recept Signal Transduct Res) Vol. 15 Issue 5 Pg. 747-56 (Apr 1995) ISSN: 1079-9893 [Print] England
• PMID: 8747884 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Receptors, Growth Factor
• Transforming Growth Factors

Topics

• Animals
• Autoradiography
• Cattle
• Epithelium (chemistry)
• Molecular Weight
• Receptors, Growth Factor (analysis)
• Transforming Growth Factors (metabolism)