A case of generalized pustular psoriasis followed by bullous disease: an atypical case of bullous pemphigoid or a novel bullous disease?

Abstract

We describe a 31-year-old Japanese woman with generalized pustular psoriasis treated with PUVA who subsequently developed a bullous disease. Throughout the disease course, there was no phase of psoriasis vulgaris. Although several reports describe coexistence of psoriasis vulgaris and bullous disease such as bullous periphigoid, coexistence of generalized pustular psoriasis without any phase of psoriasis vulgaris and bullous disease is rare. As for the bullous disease, direct immunofluorescence study showed IgG and C3 deposition along the basement membrane zone. Indirect immunofluorescence disclosed IgG antibasement membrane zone antibodies. Indirect immunofluorescence on 1 mol/l sodium chloride-split skin demonstrated linear IgG staining almost exclusively on the dermal side of the split. Western immunoblot analysis revealed that the antibody was directed to neither epidermolysis bullosa acquisita antigen nor bullous pemphigoid antigens. Considering the unusual clinical course, we suspect the possibility of a novel autoimmune blistering disease.

• Authors: H Saeki, N Hayashi, M Komine, Y Soma, S Shimada, K Watanabe, T Hashimoto
• Journal: The British journal of dermatology (Br J Dermatol) Vol. 134 Issue 1 Pg. 152-5 (Jan 1996) ISSN: 0007-0963 [Print] England
• PMID: 8745904 (Publication Type: Case Reports, Journal Article)

Chemical References

• Autoantibodies
• Immunoglobulin G

Topics

• Adult
• Autoantibodies (analysis)
• Blotting, Western
• Female
• Fluorescent Antibody Technique, Direct
• Fluorescent Antibody Technique, Indirect
• Humans
• Immunoglobulin G (analysis)
• PUVA Therapy
• Pemphigoid, Bullous (diagnosis)
• Psoriasis (complications, drug therapy)
• Skin Diseases, Vesiculobullous (etiology, immunology, pathology)