Hypotensive effects of [D-Tyr27,36, D-Thr32]Neuropeptide Y (27-36).

Abstract

An analogue of the 10 C-terminal amino acids of neuropeptide Y (NPY) containing three D-isomeric substitutions (27-36-D) has been synthesized and its cardiovascular activity studied in Sprague-Dawley (SD) and spontaneously hypertensive (SHR) rats. Intravenous administration of 1000 nmol/kg 27-36-D decreases MAP in SHR (-59.9 +/- 5.0 mmHg) and SD rats (-44.4 +/- 4.7 mmHg). The hypotension produced by 1000 nmol/kg 27-36-D diminished by 71.2% following pretreatment with the histamine receptor antagonist diphenhydramine, although histamine depletion with compound 48/80 does not significantly alter this hypotension. These data suggest that NPY (27-36)-D produces a profound and sustained hypotension in two strains of rat which is partially attributable to activity at histamine receptors.

• Authors: A K Roscoe, S M Leach, J W Nyce, W R Wooles
• Journal: Peptides (Peptides) Vol. 16 Issue 8 Pg. 1411-5 ( 1995) ISSN: 0196-9781 [Print] United States
• PMID: 8745051 (Publication Type: Journal Article)

Chemical References

• Antihypertensive Agents
• Histamine H1 Antagonists
• Neuropeptide Y
• Peptide Fragments
• Receptors, Histamine
• neuropeptide Y (27-36), Tyr(27,36)-Thr(32)-
• Diphenhydramine

Topics

• Animals
• Antihypertensive Agents (administration & dosage, pharmacology)
• Blood Pressure (drug effects, physiology)
• Diphenhydramine (pharmacology)
• Dose-Response Relationship, Drug
• Histamine H1 Antagonists (pharmacology)
• Hypertension (drug therapy, physiopathology)
• Male
• Neuropeptide Y (administration & dosage, analogs & derivatives, pharmacology)
• Peptide Fragments (administration & dosage, pharmacology)
• Rats
• Rats, Inbred SHR
• Rats, Sprague-Dawley
• Receptors, Histamine (drug effects, physiology)