Abstract | BACKGROUND AND OBJECTIVES: METHODS: RESULTS: The mRNA for the sumatriptan-activated receptors 5-HTIB, 5-HTID, and 5-HT7, was detected in lumbar dorsal root ganglia. In rat knee joint, capsaicin-activated C-fibers stimulated plasma extravasation to 273 +/- 62% of baseline. Low-concentration sumatriptan (50 nM) significantly inhibited capsaicin-induced plasma extravasation to 106 +/- 6% of baseline. High-concentration sumatriptan (1 microM) significantly enhanced capsaicin-induced plasma extravasation to 572 +/- 55% of baseline. CONCLUSIONS:
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Authors | P A Pierce, G X Xie, S J Peroutka, J D Levine |
Journal | Regional anesthesia
(Reg Anesth)
1996 May-Jun
Vol. 21
Issue 3
Pg. 219-25
ISSN: 0146-521X [Print] United States |
PMID | 8744664
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- RNA, Messenger
- Receptors, Serotonin
- Serotonin Receptor Agonists
- Sumatriptan
|
Topics |
- Animals
- Base Sequence
- Capillary Permeability
(drug effects)
- Ganglia, Spinal
- Inflammation
(chemically induced, drug therapy)
- Male
- Molecular Sequence Data
- RNA, Messenger
(analysis)
- Rats
- Rats, Sprague-Dawley
- Receptors, Serotonin
(drug effects, genetics)
- Serotonin Receptor Agonists
(pharmacology)
- Sumatriptan
(pharmacology)
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