Multiple sensory and functional effects of non-phenolic aminodimethylene nonivamide: an approach to capsaicin antagonist.

Abstract

1. Hexylaminodimethylene nonivamide (CAPCNC6, 0.1-10 microM) inhibited the contractility of isolated guinea pig right atria, toxically revealed positive inotropic, chronotropic and then a cardiac arrest effect at 100 microM and inhibited capsaicin (1.0 microM)-induced cardiotonic effects. 2. CAPCNC6 (0.1-10 microM)-induced aorta contractions were inhibited in the presence of flunarizine, atropine, phentolamine, Ca(2+)-free solution and pre-treatment of the animal with capsaicin. 3. CAPCNC6 (1.0-300 microM)-induced trachea contractions were inhibited in the presence of capsazepine, ruthenium red, hCGRP8-37 and pre-treatment of the animal with capsaicin.

• Authors: J R Wu, S F Fann, J L Yeh, Y C Lo, T Y Huang, I J Chen
• Journal: General pharmacology (Gen Pharmacol) Vol. 27 Issue 1 Pg. 151-8 (Jan 1996) ISSN: 0306-3623 [Print] England
• PMID: 8742513 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amides
• CAPCNC6
• Calcium Channel Blockers
• Vanillic Acid
• Flunarizine
• Capsaicin

Topics

• Amides
• Animals
• Aorta, Thoracic (drug effects)
• Calcium Channel Blockers
• Capsaicin (antagonists & inhibitors)
• Female
• Flunarizine (antagonists & inhibitors)
• Guinea Pigs
• Heart Atria (drug effects)
• Male
• Myocardial Contraction (drug effects)
• Rats
• Rats, Wistar
• Trachea (drug effects)
• Vanillic Acid (analogs & derivatives, pharmacology)