Effect of M-711 on experimental skin reactions induced by chemical mediators in rats.

Abstract

We investigated the mechanism of anti-allergic action of Moku-boi-to (M-711) and effects on the skin reactions induced by chemical mediators as the model of allergic dermatitis. More than 20 mg/kg BW of M-711 significantly suppressed the enhancement of capillary permeability induced by histamine, LTC4, and anti-serum in the rat skin. Anti-histaminic effect of 40 mg/kg BW of M-711 was equipotent to same as the optimal doses of azelastine and diphenhydramine, respectively. As to anti-LTC4 action, 20 mg of M-711 was compared to the optimal dose of diphenhydramine. Those data showed that M-711 has the suppressive effects on the chemical mediators such as histamine and LTC4 and reduced the skin reaction induced by antigen-antibody response.

• Authors: K Shichinohe, M Shimizu, K Kurokawa
• Journal: The Journal of veterinary medical science (J Vet Med Sci) Vol. 58 Issue 5 Pg. 419-23 (May 1996) ISSN: 0916-7250 [Print] Japan
• PMID: 8741601 (Publication Type: Journal Article)

Chemical References

• Anti-Allergic Agents
• Drugs, Chinese Herbal
• Phthalazines
• moku-boi-to
• Leukotriene C4
• Dexamethasone
• Diphenhydramine
• azelastine

Topics

• Animals
• Anti-Allergic Agents (therapeutic use)
• Dermatitis, Allergic Contact (drug therapy)
• Dexamethasone (therapeutic use)
• Diphenhydramine (therapeutic use)
• Drugs, Chinese Herbal (therapeutic use)
• Leukotriene C4 (toxicity)
• Male
• Phthalazines (therapeutic use)
• Phytotherapy
• Plants, Medicinal
• Rats
• Rats, Sprague-Dawley
• Skin Tests