A 60-year-old [correction of 68] male was referred to our hospital because of a penile
tumor with
necrosis. Pathological examination of the penile
tumor and superficial inguinal lymph nodes in biopsy revealed well differentiated
squamous cell carcinoma (SCC) and the SCC
tumor marker was elevated. TNM classification was T2, N2, M0 according to findings obtained by computed tomography (CT) and magnetic resonance imaging (MRI). We diagnosed the
tumor inoperable radically and administered 10 mg
peplomycin once a week for 10 weeks intravenously. The SCC marker level was not reduced and the
tumor was not changed on MRI. Then, we performed combined
pirarubicin treatment and
radiotherapy. The patient received linac
radiotherapy between 40 Gy/4 weeks/20 fractions.
Pirarubicin, 10 mg/m2, was administered once a week for 4 weeks during irradiation intravenously. After the combined
therapy, the SCC marked level was reduced to the normal range and the
tumor was reduced. We performed radical operation. Pathological diagnosis revealed no viable
tumor cells. The patient was alive with no evidence of disease a year later. This combined
therapy is suggested to be useful.