Abstract | OBJECTIVE: METHODS: 74 patients underwent serum PSA and procollagen determination using specific antibodies. A staging radionuclide bone scan was then performed; patients with positive bone scan were submitted to x-rays of the suspicious zones. Then, we calculated sensitivity, specificity, positive predictive value, negative predictive value and overall accuracy of procollagen and PSA in the detection of bone metastases. RESULTS:
Procollagen alone had 83.3% sensitivity, 96% specificity, 90.9% positive predictive value, 92.3% negative predictive value and 91.9% overall accuracy. PSA alone had 70.1% sensitivity, 86% specificity, 70.8% positive predictive value, 86% negative predictive value and 81.1% overall accuracy. CONCLUSIONS: According to our data, we no longer perform a staging radionuclide bone scan in patients with PSA < 20 ng/ml and normal procollagen level, diminishing the number of radionuclide bone scans and increasing the overall net savings for the health care system.
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Authors | M Perachino, L Di Ciolo, V Barbetti, P Puppo |
Journal | European urology
(Eur Urol)
Vol. 29
Issue 3
Pg. 366-9
( 1996)
ISSN: 0302-2838 [Print] Switzerland |
PMID | 8740025
(Publication Type: Journal Article)
|
Chemical References |
- Biomarkers, Tumor
- Peptide Fragments
- Procollagen
- procollagen type I carboxy terminal peptide
- Prostate-Specific Antigen
|
Topics |
- Aged
- Antibody Specificity
- Biomarkers, Tumor
(blood)
- Bone Neoplasms
(blood, diagnostic imaging, secondary)
- Humans
- Male
- Middle Aged
- Peptide Fragments
(blood)
- Predictive Value of Tests
- Procollagen
(blood)
- Prostate-Specific Antigen
(blood)
- Prostatic Neoplasms
(blood, diagnostic imaging, pathology, radiotherapy)
- Radiography
- Radionuclide Imaging
- Reproducibility of Results
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