HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Procollagen type I carboxyterminal extension peptide in serum: a reliable marker of bone metastatic disease in newly diagnosed prostate cancer?

AbstractOBJECTIVE:
This study evaluates the accuracy of type I procollagen, a bone matrix glycoprotein, and prostate-specific antigen (PSA) as markers for predicting the results of radionuclide bone scan in newly diagnosed, previously untreated patients with prostate cancer.
METHODS:
74 patients underwent serum PSA and procollagen determination using specific antibodies. A staging radionuclide bone scan was then performed; patients with positive bone scan were submitted to x-rays of the suspicious zones. Then, we calculated sensitivity, specificity, positive predictive value, negative predictive value and overall accuracy of procollagen and PSA in the detection of bone metastases.
RESULTS:
Procollagen alone had 83.3% sensitivity, 96% specificity, 90.9% positive predictive value, 92.3% negative predictive value and 91.9% overall accuracy. PSA alone had 70.1% sensitivity, 86% specificity, 70.8% positive predictive value, 86% negative predictive value and 81.1% overall accuracy.
CONCLUSIONS:
According to our data, we no longer perform a staging radionuclide bone scan in patients with PSA < 20 ng/ml and normal procollagen level, diminishing the number of radionuclide bone scans and increasing the overall net savings for the health care system.
AuthorsM Perachino, L Di Ciolo, V Barbetti, P Puppo
JournalEuropean urology (Eur Urol) Vol. 29 Issue 3 Pg. 366-9 ( 1996) ISSN: 0302-2838 [Print] Switzerland
PMID8740025 (Publication Type: Journal Article)
Chemical References
  • Biomarkers, Tumor
  • Peptide Fragments
  • Procollagen
  • procollagen type I carboxy terminal peptide
  • Prostate-Specific Antigen
Topics
  • Aged
  • Antibody Specificity
  • Biomarkers, Tumor (blood)
  • Bone Neoplasms (blood, diagnostic imaging, secondary)
  • Humans
  • Male
  • Middle Aged
  • Peptide Fragments (blood)
  • Predictive Value of Tests
  • Procollagen (blood)
  • Prostate-Specific Antigen (blood)
  • Prostatic Neoplasms (blood, diagnostic imaging, pathology, radiotherapy)
  • Radiography
  • Radionuclide Imaging
  • Reproducibility of Results

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: