Abstract |
(+)- AJ 76 is a stimulant dopamine (DA) antagonist, which has a putative preferential action at DA nerve terminal autoreceptors. Because it is both a mild stimulant and a DA antagonist, it has previously been suggested that (+)- AJ 76 might antagonize both the euphoria and craving associated with cocaine abuse and withdrawal, respectively. To evaluate this hypothesis further, (+)- AJ 76 was evaluated for its ability to affect cocaine-induced changes in regional brain energy metabolism. Using Sokoloff's 2-deoxyglucose autoradiographic technique, (+)- AJ 76 antagonized the stimulant effect of cocaine. Although classical DA antagonists are known to depress regional brain energy metabolism, (+)- AJ 76 by itself had no effect. It is concluded that the results are consistent with the previously stated hypothesis that (+)- AJ 76 might be useful as a pharmacotherapy for treatment of cocaine abuse.
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Authors | B L Casey, C A Ray, M F Piercey |
Journal | Journal of neural transmission (Vienna, Austria : 1996)
(J Neural Transm (Vienna))
Vol. 103
Issue 3
Pg. 277-85
( 1996)
ISSN: 0300-9564 [Print] Austria |
PMID | 8739839
(Publication Type: Journal Article)
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Chemical References |
- Autoreceptors
- Central Nervous System Stimulants
- Dopamine Antagonists
- Receptors, Dopamine
- Tetrahydronaphthalenes
- 5-methoxy-1-methyl-2-(n-propylamino)tetralin
- Deoxyglucose
- Cocaine
- Glucose
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Topics |
- Animals
- Autoradiography
- Autoreceptors
(drug effects, metabolism)
- Brain Chemistry
(drug effects)
- Central Nervous System Stimulants
(antagonists & inhibitors, pharmacology)
- Cocaine
(antagonists & inhibitors, pharmacology)
- Deoxyglucose
- Dopamine Antagonists
(pharmacology)
- Energy Metabolism
(drug effects)
- Glucose
(metabolism)
- Male
- Rats
- Rats, Sprague-Dawley
- Receptors, Dopamine
(drug effects, metabolism)
- Tetrahydronaphthalenes
(pharmacology)
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