Satietin: Fos mapping of putative brain sites of action.

Abstract

A purified extract of a blood-borne satiety factor, called satietin, was injected into the cerebral ventricles of rats that were either fed ad libitum or were food deprived. The animals were killed 2 h after injection and their brains subsequently sectioned and stained for Fos-like immunoreactivity (Fos-IR) to determine the putative sites of action for satietin in the brain. Fos-IR was induced in only a few locations, the most prominent sites being the bed nucleus of the stria terminalis, the central nucleus of the amygdala, and the parvocellular division of the paraventricular nucleus of the hypothalamus. Each of these areas has previously been implicated in the control of feeding behavior. Sites in the hindbrain that are associated with nausea were devoid of satietin-induced Fos-IR. Finally, these sites of action of satietin show some differences from sites that are prominently activated by other classes of anorectic agents.

• Authors: N E Rowland, L L Bellinger, B H Li, V E Mendel
• Journal: Brain research (Brain Res) Vol. 717 Issue 1-2 Pg. 189-92 (Apr 22 1996) ISSN: 0006-8993 [Print] Netherlands
• PMID: 8738271 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Appetite Depressants
• Glycopeptides
• Proto-Oncogene Proteins c-fos
• satietin

Topics

• Amygdala (chemistry)
• Animals
• Appetite Depressants (pharmacology)
• Brain Chemistry
• Brain Mapping
• Glycopeptides (pharmacology)
• Male
• Paraventricular Hypothalamic Nucleus (chemistry)
• Proto-Oncogene Proteins c-fos (analysis)
• Rats
• Rats, Sprague-Dawley
• Thalamic Nuclei (chemistry)