Abstract |
Triamcinolone acetonide (TAA) aerosol nasal inhaler has been shown to effectively relieve the symptoms of seasonal allergic rhinitis in adults and adolescents. We conducted a study to evaluate the efficacy and safety of once-daily administration of TAA aerosol nasal inhaler in pediatric patients aged 6 to 11 years with grass seasonal allergic rhinitis. This multicenter, randomized, double-blind, placebo-controlled, parallel-group study enrolled 116 children who were treated with either TAA aerosol nasal inhaler (220 micrograms/d) or placebo once daily for 2 weeks. Patients evaluated the severity of rhinitis symptoms (nasal stuffiness, discharge, sneezing, and itching) daily according to a four-point scale (0 = absent, 1 = mild, 2 = moderate, and 3 = severe). Patients' and physicians' global evaluations of overall treatment efficacy were assessed at the end of the 2-week treatment period. Patients treated with TAA aerosol nasal inhaler had significantly greater reductions in all nasal symptom scores overall and in virtually all symptoms at the end of week 1 and week 2 compared with those in the placebo group. Both patients' and physicians' global evaluations of efficacy favored TAA aerosol nasal inhaler over placebo. This study demonstrated that once-daily administration of 220 micrograms of TAA aerosol nasal inhaler was well tolerated and effectively reduced the symptoms of seasonal allergic rhinitis in pediatric patients.
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Authors | C H Banov, W S Silvers, A W Green, J H van Bavel, J A Winder, G Feiss, B Simpson, J A Furst, J A Smith |
Journal | Clinical therapeutics
(Clin Ther)
1996 Mar-Apr
Vol. 18
Issue 2
Pg. 265-72
ISSN: 0149-2918 [Print] United States |
PMID | 8733987
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Aerosols
- Anti-Inflammatory Agents
- Triamcinolone Acetonide
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Topics |
- Administration, Intranasal
- Aerosols
- Anti-Inflammatory Agents
(therapeutic use)
- Child
- Double-Blind Method
- Female
- Humans
- Male
- Rhinitis, Allergic, Seasonal
(drug therapy)
- Seasons
- Triamcinolone Acetonide
(administration & dosage, therapeutic use)
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