Abstract | BACKGROUND: METHODS: One hundred and thirty one patients believed on clinical grounds to have a operable non-small cell lung cancer were photoscanned with the indium-111 labelled F(ab')2 fragments of the antibody FO23C5. Both planar and single photoemission computed tomography (SPECT) thoracic views were recorded. CT scan of the thorax, abdomen, and brain were obtained in all patients. Seventy of the patients eventually underwent surgery, an additional seven underwent mediastinoscopy or mediastinotomy, and a further 10 had both cervical exploration and thoracotomy. Pathological evaluation of the mediastinal nodes was available in all 87 patients, but in only 80 of them was the diagnosis of lung cancer eventually confirmed. RESULTS: The diagnostic accuracy of planar immunoscintigraphy, SPECT immunoscintigraphy, and CT scanning for N2 disease was 76%, 74%, and 71%, respectively. The corresponding sensitivity and specificity rates were 45%, 77%, 64% and 88%, 72%, and 74%. These were not significantly different. CONCLUSIONS: This study shows that anti-CEA immunoscintigraphy has no advantage over conventional CT scanning in assessing mediastinal lymphoadenopathy in patients with lung cancer. CT scanning remains the gold standard test in these patients.
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Authors | G Buccheri, A Biggi, D Ferrigno, M Quaranta, A Leone, G Vassallo, F Pugno |
Journal | Thorax
(Thorax)
Vol. 51
Issue 4
Pg. 359-63
(Apr 1996)
ISSN: 0040-6376 [Print] England |
PMID | 8733485
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Monoclonal
- Carcinoembryonic Antigen
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Topics |
- Antibodies, Monoclonal
- Carcinoembryonic Antigen
(immunology)
- Carcinoma, Non-Small-Cell Lung
(diagnostic imaging, secondary)
- Evaluation Studies as Topic
- Female
- Humans
- Lung Neoplasms
(pathology)
- Lymph Nodes
(diagnostic imaging)
- Lymphatic Metastasis
- Male
- Mediastinum
- Middle Aged
- Radioimmunodetection
- Sensitivity and Specificity
- Tomography, Emission-Computed, Single-Photon
- Tomography, X-Ray Computed
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