Abstract | AIM: MATERIAL AND METHODS:
Cirrhosis was induced by intragastrically administration of carbon tetrachloride 520 mg/kg/week, during 16-19 weeks. After this period, each liver was isolated, exsanguinated and perfused at 37 degrees C with 10nM rat plasma kallikrein (RPK). RESULTS: 58% of the animals died during the treatment and the remaining developed prostration, ascites, jaundice and bleeding; at the end of the treatment period serum aminotransferases were not altered and serum albumin decreased. The liver histology showed cirrhosis. RPK clearance rate of the cirrhosis group (5.4 +/- 0.9 pmol/g liver/10 min) was significantly lower (p < 0.05) than that of the control group (13.5 +/- 2.7 pmol/g liver/10 min). CONCLUSION: The development of cirrhosis is associated with a decreased hepatic clearance of a glycoprotein which endocytosis is mediated by a receptor.
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Authors | C F de Toledo, M R Loureiro-Silva, H M Molina, V P Lanzoni, M Kouyoumdjian, D R Borges |
Journal | Revista da Associacao Medica Brasileira (1992)
(Rev Assoc Med Bras (1992))
1995 Nov-Dec
Vol. 41
Issue 6
Pg. 367-72
ISSN: 0104-4230 [Print] Brazil |
Vernacular Title | Depuração hepática da calicreína plasmática na cirrose experimental. |
PMID | 8733244
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Carbon Tetrachloride
- Kallikreins
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Topics |
- Age Factors
- Analysis of Variance
- Animals
- Body Weight
(drug effects)
- Carbon Tetrachloride
(administration & dosage)
- Kallikreins
(metabolism)
- Liver
(metabolism)
- Liver Cirrhosis, Experimental
(physiopathology)
- Metabolic Clearance Rate
- Organ Size
(drug effects)
- Perfusion
- Prognosis
- Rats
- Rats, Wistar
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