The reversal of experimental hemorrhagic shock induced by nicotine and dimethylphenylpiperazinium is adrenal-dependent.

Abstract

In a rat model of volume-controlled hemorrhagic shock causing the death of all control animals within 30 min, the intravenous injection of either nicotine (50 micrograms/kg) or dimethylphenylpiperazinium (DMPP) (0.5 micrograms/kg) produced a rapid and sustained reversal of the shock condition, with 100% survival 2 h after treatment. Bilateral adrenalectomy completely prevented the anti-shock effect of the two drugs, even though administered at higher doses (150 micrograms/kg in the case of nicotine; 10 micrograms/kg in the case of DMPP). It is concluded that stimulation of adrenaline release plays a fundamental role in the mechanism of action of nicotine- and DMPP-induced shock reversal.

• Authors: C Bazzani, A Bertolini, G M Ricigliano, M M Cainazzo, A Balugani, S Guarini
• Journal: Resuscitation (Resuscitation) Vol. 31 Issue 2 Pg. 145-50 (Apr 1996) ISSN: 0300-9572 [Print] Ireland
• PMID: 8733022 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Ganglionic Stimulants
• Dimethylphenylpiperazinium Iodide
• Nicotine

Topics

• Adrenal Glands (drug effects, metabolism)
• Adrenalectomy
• Animals
• Dimethylphenylpiperazinium Iodide (pharmacology)
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Female
• Ganglionic Stimulants (pharmacology)
• Injections, Intravenous
• Male
• Nicotine (pharmacology)
• Rats
• Rats, Wistar
• Shock, Hemorrhagic (drug therapy, physiopathology)