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Fu-Ling, a Chinese herbal drug, modulates cytokine secretion by human peripheral blood monocytes.

Abstract
Fu-Ling, the sclederma of Poria cocos (Schw.) Wolf, has long been used as a sedative and diuretic in traditional Chinese herbal medicine. Our study demonstrated that the substances extracted from Fu-Ling by 50% hot ethanol significantly augmented the secretion of interleukins IL-1 beta and IL-6 6 h after in vitro cultivation of human peripheral blood monocytes. The augmented effect was dose dependent. Tumour necrosis factor-alpha (TNF-alpha) secretion was also increased as the cells were treated with 0.4 mg/ml or higher doses of Fu-Ling extract. By contrast, Fu-Ling extract significantly suppressed the secretion of transforming growth factor-beta (TGF-beta) 3 h after the in vitro drug treatment. The suppressive effect was shown at doses as low as 0.2 mg/ml of Fu-Ling extract. Since Fu-Ling extract enhanced the secretion of immune stimulators (IL-1 beta, IL-6 and TNF-alpha) but suppressed the secretion of an immune suppressor (TGF-beta), the substance in 50% hot ethanol extract of Fu-Ling might have potentiated the immune response. Fu-Ling extract was further fractionated by reverse-phase column chromatography and high-performance liquid chromatography (HPLC). The components showing activity in modulating the cytokine secretion were relatively high in hydrophobicity.
AuthorsS J Yu, J Tseng
JournalInternational journal of immunopharmacology (Int J Immunopharmacol) Vol. 18 Issue 1 Pg. 37-44 (Jan 1996) ISSN: 0192-0561 [Print] ENGLAND
PMID8732431 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Adjuvants, Immunologic
  • Cytokines
  • Drugs, Chinese Herbal
  • Interleukin-1
  • Interleukin-6
  • Transforming Growth Factor beta
  • Tumor Necrosis Factor-alpha
  • fu ling
Topics
  • Adjuvants, Immunologic (pharmacology)
  • Cell Division (drug effects)
  • Cells, Cultured
  • Cytokines (drug effects, secretion)
  • Drugs, Chinese Herbal (isolation & purification, pharmacology)
  • Humans
  • Interleukin-1 (secretion)
  • Interleukin-6 (secretion)
  • Monocytes (cytology, drug effects, secretion)
  • Transforming Growth Factor beta (secretion)
  • Tumor Necrosis Factor-alpha (secretion)

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