Neuroprotection against CA1 injury with metalloporphyrins.

Abstract

The hippocampal slice was used to examine neuroprotection with metalloporphyrins, a class of drug which inhibits heme oxygenase and which has been found to be effective in the treatment of neonatal hyperbilirubinemia. Tin-protoporphyrin given during hypoxia significantly improved recovery of CA1 antidromic PS to a mean of 82 +/- 2% of initial amplitude, while unmedicated slices regained only 6 +/- 3% of initial amplitude. Tin-protoporphyrin also protected against fluid percussion injury with an EC50 of 10 microM when given after trauma. This protection extended to induction of long-term potentiation. Tin-mesoporphyrin and zinc-protoporphyrin protected against trauma with EC50's of 4 and 32 microM. Treatment with Sn-PP also protected against exposure to hydrogen peroxide, but not NMDA, AMPA, glycine or nitric oxide. These findings indicate that metalloporphyrins protect against CA1 neuronal injury through direct neural effects.

• Authors: K L Panizzon, B E Dwyer, R N Nishimura, R A Wallis
• Journal: Neuroreport (Neuroreport) Vol. 7 Issue 2 Pg. 662-6 (Jan 31 1996) ISSN: 0959-4965 [Print] England
• PMID: 8730852 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Metalloporphyrins
• Neuroprotective Agents

Topics

• Animals
• Brain Injuries (physiopathology)
• Electric Stimulation
• Electrophysiology
• Evoked Potentials (drug effects)
• Hypoxia, Brain (physiopathology)
• Long-Term Potentiation (drug effects)
• Male
• Metalloporphyrins (pharmacology)
• Neurons (drug effects)
• Neuroprotective Agents (pharmacology)
• Rats
• Rats, Sprague-Dawley