Cyclic peptides and depsipeptides from cyanobacteria: a review.

Abstract

An elaborate array of structurally-novel and biologically-active cyclic peptides and depsipeptides are found in blue-green algae (cyanobacteria). Several of these compounds possess structures that are similar to those of natural products from marine invertebrates. Most of these cyclic peptides and depsipeptides, such as the microcystins and the lyngbyatoxins, will probably only be useful as biochemical research tools. A few, however, have the potential for development into useful commercial products. For example, cryptophycin-1, a novel inhibitor of microtubule assembly from Nostoc sp GSV 224, shows impressive activity against a broad spectrum of solid tumors implanted in mice, including multidrug-resistant ones, and majusculamide C, a microfilament-depolymerizing agent from Lyngbya majuscula, shows potent fungicidal activity and may have use in the treatment of resistant fungal-induced diseases of domestic plants and agricultural crops.

• Authors: R E Moore
• Journal: Journal of industrial microbiology (J Ind Microbiol) Vol. 16 Issue 2 Pg. 134-43 (Feb 1996) ISSN: 0169-4146 [Print] England
• PMID: 8730577 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review)

Chemical References

• Antifungal Agents
• Antineoplastic Agents
• Peptides, Cyclic

Topics

• Amino Acid Sequence
• Animals
• Antifungal Agents (isolation & purification)
• Antineoplastic Agents (isolation & purification, therapeutic use, toxicity)
• Cyanobacteria
• Mice
• Molecular Sequence Data
• Neoplasms, Experimental (drug therapy)
• Peptides, Cyclic (chemistry, isolation & purification, toxicity)
• Structure-Activity Relationship