Abstract | PURPOSE: To demonstrate the utility of a viscoelastic substance which maintains high viscosity during phacoemulsification, we conducted a double study. METHODS: We compared in vitro the corneal endothelial protection offered by Healon, Healon GV, Provisc and Viscoat after <<traumatic>> phacoemulsification. Eight samples of ten to fifteen freshly enucleated pig eyes were operated; the first four groups were the controls, whereas the other four tested the different viscous solutions. In parallel, we determined the rheologic properties of the four viscoelastic substances in a physicS laboratory. To measure the percentage of corneal endothelial cell damage, we used the Janus Green spectrometric technique. RESULTS:
Corneal endothelial cell damage averaged 31.67% in eyes in which no viscoelastic substance was used. Damage was 14.29% in specimens that received Healon, 12.85% with Healon GV, 2.48% in the Viscoat group and 15.43 in those that received Provisc. There is a significant difference (p <0.001) between the Viscoat group and all other samples. The values of the viscosity at different shear rates and the graph of viscosities as a function of shear rate of the four viscous solutions are given. CONCLUSION:
Viscoat has a very high dynamic viscosity at high shear rate. This property and a poor cohesion provide a better corneal endothelial protection during in vitro phacoemulsification.
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Authors | C Bresciani, D A Lebuisson, M Eveillard, J L Grossiord, F Drupt, G Montefiore |
Journal | Journal francais d'ophtalmologie
(J Fr Ophtalmol)
Vol. 19
Issue 1
Pg. 39-50
( 1996)
ISSN: 0181-5512 [Print] France |
Vernacular Title | Viscosite dynamique et protection endotheliale corneenne du Healonid, du Healon GV, du Provisc et du Viscoat au cours de la phacoemulsification. |
PMID | 8729840
(Publication Type: Comparative Study, English Abstract, Journal Article)
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Chemical References |
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Topics |
- Animals
- Endothelium, Corneal
- Evaluation Studies as Topic
- Hyaluronic Acid
- Phacoemulsification
- Rheology
- Spectrophotometry
- Viscosity
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