[Subarachnoid administration of lidocaine reduces delayed neuronal damage due to forebrain ischemia in rats].

Abstract

We examined the effect of subarachnoid administration of lidocaine on delayed neuronal damage due to forebrain ischemia in rats. Sixteen rats were divided at random into two groups: lidocaine group rats (n = 8) and control group rats (n = 8) were subarachnoidally administrated lidocaine 5mg.kg-1 and normal saline, respectively, prior to ischemia. Forebrain ischemia was induced by bilateral carotid artery occlusion combined with systemic hypotension for 10 min. Cerebral perfusion-fixation was performed 7 days after ischemia, subsequent to which the brains were sectioned coronally and stained with celestine blue/acid fuchsin. In the neocortex and the hippocampal CA4 region, the lidocaine group showed less ischemic neuronal injuries than the control group. However, in the hippocampal CA1/CA3 regions and the caudoputamen, neuronal injuries in the lidocaine group were not significantly different from those in the control group. We conclude that the pre-ischemic subarachnoid administration of lidocaine reduces the delayed neuronal damage in neocortex and hippocampal CA4 region in the rat with forebrain ischemia.

• Authors: T Mizunuma, S Ohta, M Suzuki
• Journal: Masui. The Japanese journal of anesthesiology (Masui) Vol. 45 Issue 4 Pg. 421-7 (Apr 1996) ISSN: 0021-4892 [Print] Japan
• PMID: 8725595 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anesthetics, Local
• Lidocaine

Topics

• Anesthetics, Local (administration & dosage)
• Animals
• Brain Ischemia (drug therapy, pathology)
• Cell Death
• Lidocaine (administration & dosage)
• Male
• Neurons (pathology)
• Prosencephalon (pathology)
• Rats
• Rats, Sprague-Dawley
• Subarachnoid Space