Abstract | RATIONALE AND OBJECTIVES: METHODS: RESULTS: For gadopentetate dimeglumine, a fast signal increase was found immediately after intravenous injection, with a subsequent signal decay in all tumors. No difference was observed between the enhancement kinetics of different tumor types after gadopentetate dimeglumine application. Similar kinetics were found in benign lesions after injection of the blood-pool agent. However, in carcinomas the blood-pool agent displayed a slower delivery, delayed peak enhancement, and slower tumor tissue clearance or even a signal plateau of more than 30 minutes. CONCLUSIONS: Dynamic magnetic resonance imaging of breast neoplasms using a blood-pool agent may help to better differentiate between benign and malignant lesions because it demonstrates the enlarged interstitial space and increased capillary permeability in carcinomas.
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Authors | G Adam, A Mühler, E Spüntrup, J M Neuerburg, M Kilbinger, H Bauer, L Fücezi, W Küpper, R W Günther |
Journal | Investigative radiology
(Invest Radiol)
Vol. 31
Issue 5
Pg. 267-74
(May 1996)
ISSN: 0020-9996 [Print] United States |
PMID | 8724124
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Contrast Media
- Drug Combinations
- Organometallic Compounds
- Polymers
- gadolinium-diethylenetriaminepentaacetic acid-cascade-polymer
- Meglumine
- Pentetic Acid
- Gadolinium DTPA
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Topics |
- Adenoma
(diagnosis, surgery)
- Animals
- Carcinoma
(diagnosis, surgery)
- Contrast Media
- Dog Diseases
(diagnosis, surgery)
- Dogs
- Drug Combinations
- Female
- Gadolinium DTPA
- Infusions, Intravenous
- Magnetic Resonance Imaging
- Mammary Neoplasms, Animal
(diagnosis, surgery)
- Meglumine
- Organometallic Compounds
- Pentetic Acid
(analogs & derivatives)
- Polymers
- Retrospective Studies
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