Abstract |
The efficacy of doxycycline and ciprofloxacin against an experimental plague infection was assessed by comparing the median lethal dose (MLD) of Yersinia pestis in antibiotic-treated and untreated mice. The MLD of Y. pestis GB strain in untreated mice by the intra-peritoneal route was 23 cfu. If ciprofloxacin dosage (20 or 40 mg/kg twice daily) was initiated 48 h before infection, it afforded complete protection against an intra-peritoneal challenge of 5.24 x 10(7) cfu. Ciprofloxacin therapy initiated 24 h post-challenge was less protective, the MLD was raised to 2.0 x 10(5) and 2.2 x 10(5) cfu for 40 and 20 mg/kg respectively. Doxycycline dosage (40 mg/kg twice daily) initiated 48 h prior to infection raised the MLD to 1.6 x 10(4) cfu, but other prophylactic and therapeutic regimes were ineffective against challenges greater than 6.76 x 10(2) cfu. Ciprofloxacin may therefore be a useful antibiotic to consider for the treatment of plague.
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Authors | P Russell, S M Eley, D L Bell, R J Manchee, R W Titball |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 37
Issue 4
Pg. 769-74
(Apr 1996)
ISSN: 0305-7453 [Print] England |
PMID | 8722542
(Publication Type: Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Anti-Infective Agents
- Ciprofloxacin
- Doxycycline
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Topics |
- Animals
- Anti-Bacterial Agents
(therapeutic use)
- Anti-Infective Agents
(therapeutic use)
- Ciprofloxacin
(therapeutic use)
- Doxycycline
(therapeutic use)
- Mice
- Plague
(drug therapy)
- Yersinia pestis
(drug effects)
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