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The role of gastric mucosal sulphydryls in the ulcer-protecting effects of cisapride.

Abstract
The present study was designed to examine the role of endogenous sulphydryls (SHs) in the gastro-protection induced by cisapride (CIS) (10, 25 and 50 mg kg-1 i.p.), a potent benzamide stimulating gastrointestinal motility in mucosal injury induced by 50% v/v ethanol. Results were compared with those of 5-hydroxytryptamine (5-HT) (10mg kg-1). Ethanol mucosal damage was significantly reduced by treatment with CIS and 5-HT. On the contrary, administration of n-ethylmaleimide (NEM) (10 mg kg-1) an SH alkylator, markedly worsened lesion formation and counteracted the protective effect of CIS. Rats pretreated with CIS significantly increased the total sulphydryls as reflected in the non-protein and protein fractions however, 5-HT treatment showed a fall in the non-protein level. The present results suggest that 5-HT-ergic dependent mechanisms have no relation to the gastro-protection afforded by CIS in this experimental model. It is possible that mucosal SHs could be involved.
AuthorsA López, V Motilva, C Alarcón de la Lastra, M J Martín, C La Casa
JournalThe Journal of pharmacy and pharmacology (J Pharm Pharmacol) Vol. 48 Issue 1 Pg. 37-40 (Jan 1996) ISSN: 0022-3573 [Print] England
PMID8722492 (Publication Type: Journal Article)
Chemical References
  • Anti-Ulcer Agents
  • Piperidines
  • Sulfhydryl Compounds
  • Sulfhydryl Reagents
  • Serotonin
  • Ethanol
  • Ethylmaleimide
  • Cisapride
Topics
  • Animals
  • Anti-Ulcer Agents (administration & dosage, pharmacology, therapeutic use)
  • Cisapride
  • Disease Models, Animal
  • Ethanol (toxicity)
  • Ethylmaleimide (administration & dosage, metabolism, toxicity)
  • Gastric Mucosa (chemistry, drug effects, metabolism)
  • Injections, Intraperitoneal
  • Injections, Subcutaneous
  • Male
  • Piperidines (administration & dosage, pharmacology, therapeutic use)
  • Rats
  • Rats, Wistar
  • Serotonin (administration & dosage, pharmacology, therapeutic use)
  • Stomach Ulcer (chemically induced, drug therapy)
  • Sulfhydryl Compounds (analysis, physiology)
  • Sulfhydryl Reagents (administration & dosage, metabolism, toxicity)

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