HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Design of clinical trials for drug combinations: cytomegalovirus retinitis--foscarnet and ganciclovir. The CMV retinitis retreatment trial.

Abstract
The Cytomegalovirus Retinitis Retreatment Trial was a multicenter clinical trial designed to evaluate three treatments for the treatment of relapsed CMV retinitis; (1) foscarnet; (2) 'high-dose' ganciclovir, and (3) combination foscarnet and ganciclovir. Two hundred seventy-nine patients were enrolled and randomly assigned to one of these three regimens. Patients were followed monthly for 6 months and every 3 months thereafter. Outcomes of interest included: (1) mortality; (2) retinitis progression; (3) change in retinal area affected by CMV; (4) loss of visual field; (5) loss of visual acuity; (6) quality of life; and (7) treatment side effects.
AuthorsD A Jabs
JournalAntiviral research (Antiviral Res) Vol. 29 Issue 1 Pg. 69-71 (Jan 1996) ISSN: 0166-3542 [Print] Netherlands
PMID8721550 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antiviral Agents
  • Foscarnet
  • Ganciclovir
Topics
  • Acquired Immunodeficiency Syndrome (complications, drug therapy, mortality)
  • Antiviral Agents (adverse effects, therapeutic use)
  • Cytomegalovirus Retinitis (drug therapy, mortality)
  • Disease Progression
  • Drug Therapy, Combination
  • Foscarnet (administration & dosage, adverse effects, therapeutic use)
  • Ganciclovir (administration & dosage, adverse effects, therapeutic use)
  • Humans
  • Multicenter Studies as Topic
  • Randomized Controlled Trials as Topic
  • Research Design

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: