The influence of
KU-1257 on the recurrence and relapse of
acetic acid ulcers in rats was investigated grossly and histologically in comparison with that of
cimetidine. The
ulcer was induced by topical application of
glacial acetic acid at the junction of the corpus and antrum on the anterior wall of the stomach. The
drug was administered from the 5th to the 153rd day after the
ulcer induction and then discontinued to the 238th day. The healing rates of the control groups (control) rose until the 119th day after the
ulcer induction, followed by ups and downs. The quality of healing in the regenerated mucosa and the granulation tissue of the healed
ulcer was poor, resulting in the recurrence and relapse of
ulcers. The recurrence and relapse of
ulcers also occurred in the
cimetidine groups (CIM). On the other hand, the
KU-1257 groups (KU-1257) showed much lower recurrence and relapse rates of
ulcers than the control and CIM groups. Moreover,
KU-1257, unlike CIM, improved the quality of
ulcer healing throughout the period of its administration and even after it was discontinued. These results suggest that
KU-1257 improves the quality of
ulcer healing, and this may contribute to the low recurrence and relapse rates of
ulcers.