We compared the effects of
semotiadil, a novel Ca2+ channel blocker, with those of
diltiazem on survival and regression of
right ventricular hypertrophy and media thickening of pulmonary arteries in a rat model of
pulmonary hypertension.
Pulmonary hypertension was induced by a single injection of
monocrotaline (80 mg/kg). Four weeks later, after
pulmonary hypertension was confirmed,
oral administration of
semotiadil (10, 30, or 100 mg/kg/day) or
diltiazem (100 or 300 mg/kg/day) was initiated. The rats were observed for 3 weeks. Survival was significantly longer in the group that received
semotiadil 100 mg/kg/day than in the groups treated with
diltiazem 100 or 300 mg/kg/day. Media thickness and smooth muscle area in pulmonary arteries were significantly less in rats treated with
semotiadil 100 mg/kg/day than in animals treated with
diltiazem 100 mg/kg/day. The right ventricle to left ventricle mass ratio, right ventricular wall thickness, and right ventricular myocardial fiber diameter were equal in these two groups.
Semotiadil 100 mg/kg/day improved the survival of rats, which responded with a significant regression of
right ventricular hypertrophy and media thickening of pulmonary arteries in comparison with rats treated with
diltiazem 100 or 300 mg/kg/day.