Ginsenoside Rh4, a genuine dammarane glycoside from Korean red ginseng.

Abstract

A genuine glycoside, named ginsenoside Rh4, was isolated from Korean red ginseng (Panax ginseng C. A. Meyer) through repeated column chromatography, and its chemical structure was established to be 6-O-beta-D-glucopyranosyldammar-20(22),24-diene-3 beta,6 alpha,12 beta-triol by spectral and chemical methods. The stereochemistry of a double bond at C-20(22) of ginsenoside Rh4 was characterized as (E) from a NOESY experiment in the 1H-NMR of the aglycone. Cytotoxic activities of ginsenoside Rh4 and its aglycone against cancer cell lines were evaluated by use of the SRB method.

• Authors: N I Baek, D S Kim, Y H Lee, J D Park, C B Lee, S I Kim
• Journal: Planta medica (Planta Med) Vol. 62 Issue 1 Pg. 86-7 (Feb 1996) ISSN: 0032-0943 [Print] Germany
• PMID: 8720394 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Ginsenosides
• Saponins
• ginsenoside Rh4

Topics

• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Carbohydrate Sequence
• Ginsenosides
• Magnetic Resonance Spectroscopy
• Molecular Sequence Data
• Panax (chemistry)
• Plants, Medicinal
• Saponins (chemistry, isolation & purification, pharmacology)
• Tumor Cells, Cultured