AT1 receptor antagonist, TCV 116, does not prevent cardiac hypertrophy in salt-loaded Dahl salt-sensitive rats.

Abstract

1. We investigated the effects of direct blockade of angiotensin II (AngII) by a potent, non-peptide angiotensin II toff 1 (AT1) receptor antagonist, TCV 116, on the development of cardiac hypertrophy in salt-loaded Dahl salt-sensitive rats. 2. Six week old male Dahl salt-sensitive rats (n = 44) were fed a 4% salt diet and were simultaneously given various doses of TCV 116 orally for 7 weeks. Each control group received vehicle alone. 3. Dietary high salt intake elevated blood pressure continuously and caused left ventricular hypertrophy in rats treated with vehicle. TCV 116 had a minor effect on the rise in blood pressure. Left ventricular mass (left ventricular weight/body-weight) decreased slightly but not significantly, in rats treated with 3 mg/kg per day of TCV 116 (n = 8). Higher doses of TCV 116 (6 and 10 mg/kg per day; n = 8 each) did not show a decrease in left ventricular mass compared with the vehicle control. 4. These results suggest that AngII blockade has only minor effects on hypertension and on cardiac hypertrophy in salt-loaded Dahl salt-sensitive rats and that the renin-angiotensin system may not contribute to the development of cardiac hypertrophy in Dahl salt-sensitive rats on a moderately high-salt diet.

• Authors: K Sugimoto, E Gotoh, I Takasaki, T Ebina, T Iwamoto, T Takizawa, H Shionoiri, M Ishii
• Journal: Clinical and experimental pharmacology & physiology (Clin Exp Pharmacol Physiol) Vol. 23 Issue 4 Pg. 282-6 (Apr 1996) ISSN: 0305-1870 [Print] Australia
• PMID: 8717062 (Publication Type: Journal Article)

Chemical References

• Angiotensin Receptor Antagonists
• Antihypertensive Agents
• Benzimidazoles
• Biphenyl Compounds
• Prodrugs
• Sodium, Dietary
• Tetrazoles
• candesartan cilexetil

Topics

• Angiotensin Receptor Antagonists
• Animals
• Antihypertensive Agents (pharmacology)
• Benzimidazoles (pharmacology)
• Biphenyl Compounds (pharmacology)
• Blood Pressure (drug effects)
• Body Weight
• Dose-Response Relationship, Drug
• Hypertension (drug therapy)
• Hypertrophy, Left Ventricular (etiology, prevention & control)
• Male
• Prodrugs (pharmacology)
• Random Allocation
• Rats
• Sodium, Dietary (adverse effects)
• Tetrazoles