Putative linkage between HLA class I polymorphism and the susceptibility to malignant melanoma.

Abstract

Human leukocyte antigen (HLA) frequencies in 67 melanoma patients were compared to 120 controls in Japan. The frequency of HLA-B13 was increased in melanoma patients compared to controls and was particularly common in nodular melanoma HLA-B61 was decreased in melanoma patients. Almost 50% of acral lentiginous melanoma patients expressed HLA-B51 compared to 0% of nodular melanomas.

• Authors: M Ichimiya, M Muto, Y Hamamoto, A Ohmura, H Tateno, C Asagami
• Journal: The Australasian journal of dermatology (Australas J Dermatol) Vol. 37 Suppl 1 Pg. S39 (May 1996) ISSN: 0004-8380 [Print] Australia
• PMID: 8713011 (Publication Type: Journal Article)

Chemical References

• HLA Antigens
• HLA-A Antigens
• HLA-B Antigens

Topics

• Asian People (genetics)
• Disease Susceptibility (ethnology)
• Genetic Predisposition to Disease
• HLA Antigens (genetics)
• HLA-A Antigens (genetics)
• HLA-B Antigens (genetics)
• Humans
• Japan
• Melanoma (ethnology, genetics)
• Polymorphism, Genetic
• Reference Values
• Skin Neoplasms (ethnology, genetics)