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[Randomized controlled study on adjuvant immunochemotherapy with carmofur (HCFU) for noncuratively resected and unresected gastric cancer].

Abstract
To evaluate the efficacy of adjuvant immunochemotherapy, especially the long-term administration of HCFU to patients with noncuratively resected and unresected gastric cancer, a randomized controlled study was conducted by 16 institutions in Hokkaido. After surgery, 185 patients were divided into two groups using the envelope method; group A (84 patients) treated by MMC (4 mg, twice a week, total 1 mg/kg)+OK-432 (or PSK): group B (101 patients) treated with MMC+OK-432+HCFU (600 mg, per day). The 5- and 10-year survival rates were 9.8 and 3.1% in group A, and 11.1 and 11.1% in group B (p=0.062). Better survival rates were obtained in those cases with unresected, S3, or peritoneal dissemination in group B. These results suggested the long-term administration of HCFU was effective for noncuratively resected and unresected gastric cancer.
AuthorsS Osawa, H Shiroto, Y Kondo, Y Nakanishi, J Fujisawa, K Miyakawa, T Oku, A Nishimura, J Uchino
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 23 Issue 3 Pg. 327-31 (Feb 1996) ISSN: 0385-0684 [Print] Japan
PMID8712826 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Picibanil
  • Mitomycin
  • carmofur
  • Fluorouracil
Topics
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Chemotherapy, Adjuvant
  • Chi-Square Distribution
  • Combined Modality Therapy
  • Fluorouracil (administration & dosage, analogs & derivatives)
  • Follow-Up Studies
  • Humans
  • Immunotherapy
  • Japan
  • Mitomycin (administration & dosage)
  • Picibanil (administration & dosage)
  • Stomach Neoplasms (drug therapy, surgery, therapy)

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