[Use of benzofurocaine in stimulation of regenerative processes in the surgical treatment of patients with chronic suppurative otitis media].

Abstract

Healing of postoperative wounds of the middle ear treated with benzofurocaine was analysed in 57 patients. The drug was given for 10 postoperative days as 10 ml intramuscular injections of 1% solution twice a day. Benzofurocaine-treated patients exhibited less extensive edema of the parotid tissues and walls of the external acoustic meatus, faster epidermisation of the trepanation cavity and retention of the neotympanum graft. Cytochemically, intramuscular injections of benzofurocaine enhance functional activity of epitheliocyte nuclei as shown by reduced DNA anisotropy and intensified cell utilization of glycogen and release of cationic protein.

• Authors: F V Semenov, I B Gorbonosov, A A Evglevskiĭ, A K Volik
• Journal: Vestnik otorinolaringologii (Vestn Otorinolaringol) 1996 Mar-Apr Issue 2 Pg. 45-8 ISSN: 0042-4668 [Print] Russia (Federation)
• Vernacular Title: Primenenie benzofurokaina dlia stimuliatsii renenerativnykh protsessov pri khirurgicheskom lechenii bol'nykh khronicheskim gnoĭnym srednim otitom.
• PMID: 8711847 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article)

Chemical References

• Anesthetics, Local
• Anti-Inflammatory Agents, Non-Steroidal
• Benzofurans
• benzofurocaine

Topics

• Adolescent
• Adult
• Aged
• Anesthetics, Local (administration & dosage, pharmacology)
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, pharmacology)
• Benzofurans
• Chronic Disease
• Humans
• Injections, Intramuscular
• Middle Aged
• Otitis Media, Suppurative (surgery)
• Regeneration (drug effects)
• Stimulation, Chemical
• Time Factors
• Wound Healing (drug effects)