Increased urinary levels of Tamm-Horsfall glycoprotein suggest a systemic etiology of interstitial cystitis.

Abstract

PURPOSE:

We investigated the role of Tamm-Horsfall protein in interstitial cystitis.

MATERIALS AND METHODS:

Urinary Tamm-Horsfall protein excretion was analyzed in interstitial cystitis patients and controls, and bladder biopsy specimens were stained immunohistochemically for Tamm-Horsfall protein.

RESULTS:

Urinary Tamm-Horsfall protein levels in 28 women with interstitial cystitis were statistically significantly greater than those in 25 female controls. No positive staining for Tamm-Horsfall protein was demonstrated in the bladder tissue from 10 interstitial cystitis cases.

CONCLUSIONS:

The results support the notion that interstitial cystitis may have a systemic etiology. In addition, this assay might have clinical value in the diagnosis of interstitial cystitis.

• Authors: J J Bade, J Marrink, A Karrenbeld, L van der Weele, H J Mensink
• Journal: The Journal of urology (J Urol) Vol. 156 Issue 3 Pg. 943-6 (Sep 1996) ISSN: 0022-5347 [Print] United States
• PMID: 8709369 (Publication Type: Journal Article)

Chemical References

• Mucoproteins
• UMOD protein, human
• Uromodulin

Topics

• Adult
• Aged
• Cystitis, Interstitial (etiology, urine)
• Female
• Humans
• Male
• Middle Aged
• Mucoproteins (urine)
• Prospective Studies
• Uromodulin