Abstract | PURPOSE: To assess the performance and the potential clinical impact of a new antibody imaging agent, CEA-Scan (Immunomedics Inc, Morris Plains, NJ), in 210 presurgical patients with advanced recurrent or metastatic colorectal carcinomas. METHODS:
CEA-Scan, an anti- carcinoembryonic antigen (CEA) Fab antibody fragment labeled with technetium-99m-pertechnetate (99mTc), was injected intravenously (IV), and external scintigraphy was performed 2 to 5 and 18 to 24 hours later. Imaging with conventional diagnostic modalities (CDM) was also performed, and findings were confirmed by surgery and histology. RESULTS: The sensitivity of CEA-Scan was superior to that of CDM in the extrahepatic abdomen (55% v 32%; P = .007) and pelvis (69% v 48%; P = .005), and CEA-Scan findings complemented those of CDM in the liver. Among 122 patients with known disease, the positive predictive value was significantly higher when both modalities were positive (98%) compared with each alone (68% to 70%), potentially obviating the need for histologic confirmation when both tests are positive. Imaging accuracy also was significantly improved by adding CEA-Scan to CDM. In 88 patients with occult cancer, imaging accuracy was enhanced significantly by CEA-Scan combined with CDM (61% v 33%). Potential clinical benefit from CEA-Scan was demonstrated in 89 of 210 patients. Only two patients developed human antimouse antibodies (HAMA) to CEA-Scan after a single injection, and none of 19 assessable patients after two injections. CONCLUSION:
CEA-Scan affords high-quality, same-day imaging, uses an inexpensive and readily available radio-nuclide, adds clinically significant information in assessing extent and location of disease in colorectal cancer patients, and only rarely induces a HAMA response.
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Authors | F L Moffat Jr, C M Pinsky, L Hammershaimb, N J Petrelli, Y Z Patt, F S Whaley, D M Goldenberg |
Journal | Journal of clinical oncology : official journal of the American Society of Clinical Oncology
(J Clin Oncol)
Vol. 14
Issue 8
Pg. 2295-305
(Aug 1996)
ISSN: 0732-183X [Print] United States |
PMID | 8708720
(Publication Type: Clinical Trial, Clinical Trial, Phase III, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antibodies, Monoclonal
- Carcinoembryonic Antigen
- Immunoglobulin Fab Fragments
- Sodium Pertechnetate Tc 99m
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Topics |
- Antibodies, Monoclonal
- Carcinoembryonic Antigen
(immunology)
- Colonic Neoplasms
(diagnostic imaging)
- Humans
- Immunoglobulin Fab Fragments
- Male
- Middle Aged
- Predictive Value of Tests
- Prospective Studies
- Radioimmunodetection
- Rectal Neoplasms
(diagnostic imaging)
- Sensitivity and Specificity
- Sodium Pertechnetate Tc 99m
- United States
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