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Effects of fenprostalene and estradiol-17 beta benzoate on parturition and retained placenta in dairy cows and heifers.

Abstract
It was hypothesized that a high dose of estrogen in conjunction with a long-acting PGF2 alpha analog would synchronize parturition within a narrow time frame and reduce the incidence of retained placenta. On d 276 of gestation, 14 animals (9 cows and 5 heifers) per group received a placebo (group A), 1 mg of fenprostalene (group B), 50 mg of estradiol-17 beta benzoate (group C), or both (group D). Treatment with estradiol-17 beta benzoate increased serum concentrations of estradiol-17 beta from 228 pg/ml at treatment to 642 and 683 pg/ml at 24 h posttreatment for groups C and D, respectively. Concentration of estradiol-17 beta in group A increased gradually to 526 pg/ml at 24 h prepartum. Progesterone concentrations were reduced by fenprostalene but not by estradiol-17 beta benzoate. Estradiol-17 beta benzoate did not reduce incidence of retained placenta in animals treated with fenprostalene (group B vs. group D) but tended to reduce incidence in uninduced animals (group A vs. group C). Thus, short-term elevation of estradiol-17 beta to normal prepartum concentrations did not regress the corpus luteum, induce parturition, or reduce incidence of retained placenta. However, elevation of estradiol-17 beta for longer periods might enhance placental separation. Conversely, fenprostalene induced calving approximately 2 d after treatment. In this study, 90% of animals treated with fenprostalene calved within a 20-h period, but with a high incidence of retained placenta.
AuthorsF E Rasmussen, M C Wiltbank, J O Christensen, R R Grummer
JournalJournal of dairy science (J Dairy Sci) Vol. 79 Issue 2 Pg. 227-34 (Feb 1996) ISSN: 0022-0302 [Print] United States
PMID8708084 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Prostaglandins F, Synthetic
  • Progesterone
  • Estradiol
  • fenprostalene
Topics
  • Animals
  • Cattle (physiology)
  • Cattle Diseases (prevention & control)
  • Estradiol (blood, pharmacology, therapeutic use)
  • Female
  • Kinetics
  • Labor, Obstetric (drug effects)
  • Placenta, Retained (prevention & control, veterinary)
  • Pregnancy
  • Progesterone (blood)
  • Prostaglandins F, Synthetic (pharmacology, therapeutic use)

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