Abstract | OBJECTIVE: DESIGN: Multi-institutional, uncontrolled, observational trial. SETTING: Six pediatric intensive care units of tertiary medical centers. PATIENTS: INTERVENTIONS: Up to four doses of intratracheal surfactant (80 mL/m2). MEASUREMENTS AND MAIN RESULTS:
Ventilator parameters, arterial blood gases, and derived oxygenation and ventilation indices were recorded before, and at intervals after, surfactant administration. Complications and outcome measures were also noted. There was immediate improvement in oxygenation and moderation of ventilator support associated with surfactant administration in 24 of 29 patients. A modest but statistically insignificant effect was seen with subsequent doses. The only complications occurred in three patients who developed airleaks, two of which were coincident with surfactant administration. The overall mortality rate was 14%, which compares favorably with other published series. CONCLUSIONS:
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Authors | D F Willson, J H Jiao, L A Bauman, A Zaritsky, H Craft, K Dockery, D Conrad, H Dalton |
Journal | Critical care medicine
(Crit Care Med)
Vol. 24
Issue 8
Pg. 1316-22
(Aug 1996)
ISSN: 0090-3493 [Print] United States |
PMID | 8706485
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Acute Disease
- Adolescent
- Animals
- Cattle
- Child
- Child, Preschool
- Female
- Humans
- Infant
- Intensive Care Units, Pediatric
- Male
- Prospective Studies
- Pulmonary Surfactants
(therapeutic use)
- Respiration, Artificial
- Respiratory Distress Syndrome
(drug therapy, therapy)
- Respiratory Insufficiency
(drug therapy, mortality, therapy)
- Treatment Outcome
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