[The neuromediator mechanism of the additive action of the delta sleep-inducing peptide in experimental audiogenic epilepsy caused by hypokinesia].

Abstract

The DSIP influence on the rat cortex, thalamic and hypothalamic adrenaline, noradrenaline, DOPA, dopamine and serotonin level under normal, hypokinetic stress condition (1 h in duration) and experimental audiogenic epilepsy was studied. It was found, that a single intraperitoneal DSIP injection (12 microns/100 g body weigh, 1 h before placing the animals into the stress condition) prevented spontaneous epileptic activity development due to creation of optimal ratio between monoamines in brain structures.

• Authors: A M Mendzheritskiĭ, N I Uskova, A V Lysenko, Iu V Revinskiĭ
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 1996 Jan-Feb Vol. 59 Issue 1 Pg. 8-10 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Neĭromediatornyĭ mekhanizm adaptivnogo deĭstviia del'ta-son indutsiruiushchego peptida pri éksperimental'noĭ audiogennoĭ épilepsii, vyzvannoĭ gipokinezieĭ.
• PMID: 8704643 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Catecholamines
• Neurotransmitter Agents
• Delta Sleep-Inducing Peptide

Topics

• Acoustic Stimulation (methods)
• Animals
• Brain Chemistry (drug effects)
• Catecholamines (analysis)
• Cerebral Cortex (chemistry, drug effects)
• Delta Sleep-Inducing Peptide (pharmacology)
• Epilepsy (etiology, metabolism)
• Female
• Hypokinesia (complications, metabolism)
• Hypothalamus (chemistry, drug effects)
• Male
• Neurotransmitter Agents (pharmacology)
• Rats
• Thalamus (chemistry, drug effects)