[The efficacy of hepatoprotective agents in experimental chronic hepatitis].

Abstract

Hepatoprotective drugs eplyr, essential, salsocollin, macsar and legalon in rats with chronic CCl4 hepatosis prevent fibrosis development, inflammatory infiltration of portal tracts, dystrophia and hepatocytes necrosis, reduce the content of hepatic glycoseaminoglycanes, oxyproline and different collagenic fractions in liver, weaken manifestations of cytolytic and cholestatic syndromes, improve antitoxic hepar function.

• Authors: A S Saratikov, Vengerovskiĭ, N O Baturina, V S Chuchalin
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 1996 Jan-Feb Vol. 59 Issue 1 Pg. 24-6 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Effektivnost' gepatozashchitnykh sredstv pri éksperimental'nom khronicheskom gepatite.
• PMID: 8704626 (Publication Type: Comparative Study, Journal Article)

Topics

• Animals
• Carbon Tetrachloride Poisoning (complications, drug therapy, metabolism, pathology)
• Chemical and Drug Induced Liver Injury (drug therapy, etiology, metabolism, pathology)
• Chronic Disease
• Drug Evaluation, Preclinical
• Liver (drug effects, metabolism, pathology)
• Male
• Rats