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Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease.

AbstractAIM:
To evaluate the efficacy and safety of tablet huperzine-A (Hup) in patients with Alzheimer's disease.
METHODS:
Using multicenter, prospective, double-blind, parallel, placebo controlled and randomized method, 50 patients were administered orally 0.2 mg (4 tablets) Hup and 53 patients were given po 4 tablets of placebo bid for 8 wk. All patients were evaluated with Wechsler memory scale, Hasegawa dementia scale, mini-mental state examination scale, activity of daily living scale, treatment emergency symptom scale, and measured with BP, HR, ECG, EEG, ALT, AKP, BUN, Cr, Hb, WBC, and urine routine.
RESULTS:
About 58% (29/50) of patients treated with Hup showed improvements in their memory (P < 0.01), cognitive (P < 0.01), and behavioral (P < 0.01 functions. The efficacy of Hup was better than placebo (36%, 19/53) (P < 0.05). No severe side effect was found.
CONCLUSION:
Hup is a promising drug for symptomatic treatment of Alzheimer's disease.
AuthorsS S Xu, Z X Gao, Z Weng, Z M Du, W A Xu, J S Yang, M L Zhang, Z H Tong, Y S Fang, X S Chai
JournalZhongguo yao li xue bao = Acta pharmacologica Sinica (Zhongguo Yao Li Xue Bao) Vol. 16 Issue 5 Pg. 391-5 (Sep 1995) ISSN: 0253-9756 [Print] China
PMID8701750 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Alkaloids
  • Cholinesterase Inhibitors
  • Sesquiterpenes
  • Tablets
  • huperzine A
Topics
  • Aged
  • Aged, 80 and over
  • Alkaloids
  • Alzheimer Disease (drug therapy, psychology)
  • Behavior (drug effects)
  • Cholinesterase Inhibitors (therapeutic use)
  • Cognition (drug effects)
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Memory (drug effects)
  • Middle Aged
  • Prospective Studies
  • Sesquiterpenes (therapeutic use)
  • Tablets

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