[Acute porphyria and multiple organ failure during treatment with lamotrigine].

Abstract

A 38-year-old female suffered from an acute porphyric attack, multi-organ failure and disseminated intravascular coagulation (DIC) within two weeks of starting lamotrigine, a new antiepileptic drug. The porphyric attack was characterized by excess urinary excretion of aminolevulinic acid (ALA), porphobilinogen (PBG) and coproporphyrin III, a pattern similar to that seen in hereditary coproporphyria, however the diagnostic criteria for this specific porphyria were not fulfilled. We suggest that the observed clinical picture represents a rare adverse reaction to lamotrigine.

• Authors: H Gregersen, J S Nielsen, N A Peterslund
• Journal: Ugeskrift for laeger (Ugeskr Laeger) Vol. 158 Issue 28 Pg. 4091-2 (Jul 08 1996) ISSN: 0041-5782 [Print] Denmark
• Vernacular Title: Akut porfyri og multiorgansvigt under behandling med lamotrigin.
• PMID: 8701527 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anticonvulsants
• Triazines
• Lamotrigine

Topics

• Adult
• Anticonvulsants (adverse effects)
• Disseminated Intravascular Coagulation (chemically induced)
• Female
• Humans
• Lamotrigine
• Multiple Organ Failure (chemically induced)
• Porphyria, Acute Intermittent (chemically induced)
• Triazines (adverse effects)