[Effect of dalargin on healing of a bullet wound of the soft tissues in rabbits].

Abstract

Reparative processes were studied by using an experimental model based on a bullet wound in the rabbit's leg soft tissue. The effect of dalargin (10 mg/kg for a 14-day course) was shown in its reducing posttraumatic edema, hemorrhages, and tissue inflammation, as well as conductive demarcation of necrosis. Dalargin was found to stimulate the proliferation of epidermal cells, the formation and transformation of granulations. With the peptide, the phagocytic functions of neutrophils were restored and hyperfermentemia was reduced. The findings suggest that dalargin is a promising agent in stimulating the reparative processes in the gun-shot wound.

• Authors: V P Legeza, A G Koshcheev, L N Konovalova
• Journal: Patologicheskaia fiziologiia i eksperimental'naia terapiia (Patol Fiziol Eksp Ter) 1995 Oct-Dec Issue 4 Pg. 45-8 ISSN: 0031-2991 [Print] Russia (Federation)
• Vernacular Title: Vliianie dalargina na zazhivlenie ognestrel'noĭ rany miagkikh tkaneĭ u krolikov.
• PMID: 8700598 (Publication Type: Journal Article)

Chemical References

• Enkephalin, Leucine-2-Alanine
• enkephalin-Leu, Ala(2)-Arg(6)-

Topics

• Animals
• Enkephalin, Leucine-2-Alanine (analogs & derivatives, therapeutic use)
• Rabbits
• Soft Tissue Injuries (drug therapy, etiology)
• Wound Healing (drug effects)
• Wounds, Gunshot (drug therapy)