Diabetes mellitus and islet amyloidosis in cynomolgus monkeys.

Abstract

Six 15- to 20-year-old obese cynomolgus monkeys were determined to have diabetes mellitus. These monkeys were hyperglycemic and hypertriglyceridemic, yet remained nonketotic for several years before requiring clinical intervention. A significant decrease in glucose disappearance and an increased area under the glucose disappearance curve were found in response to intravenous glucose tolerance testing. Basal hyperinsulinemia was found in three animals that, in response to glucose stimulation, had a blunted insulin response, resulting in an overall decrease in the area under the insulin curve. Two animals died during the study and had extensive amyloid infiltration of pancreatic islets. The combined findings of old age, obesity, hyperinsulinemia, improvement in response to caloric restriction, and islet amyloidosis are consistent with type 2 diabetes mellitus.

• Authors: J D Wagner, C S Carlson, T D O'Brien, M S Anthony, B C Bullock, W T Cefalu
• Journal: Laboratory animal science (Lab Anim Sci) Vol. 46 Issue 1 Pg. 36-41 (Feb 1996) ISSN: 0023-6764 [Print] United States
• PMID: 8699817 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Blood Glucose
• Insulin
• Triglycerides

Topics

• Adipose Tissue (metabolism)
• Amyloidosis (metabolism, pathology, veterinary)
• Animals
• Blood Glucose (metabolism)
• Confidence Intervals
• Diabetes Mellitus, Type 2 (metabolism, pathology, veterinary)
• Female
• Glucose Tolerance Test
• Insulin (analysis)
• Islets of Langerhans (pathology)
• Macaca fascicularis
• Male
• Monkey Diseases (metabolism, pathology)
• Pancreatic Diseases (metabolism, pathology, veterinary)
• Triglycerides (blood)