A novel adrenaline derivative, AZ002, and its hypoglycemic action in yellow KK mice.

Abstract

AZ002 (L-threo-(3,4-dihydroxy phenyl)-N-methyl serine methyl ester) is a newly synthesized adrenaline derivative. AZ002 caused relaxation of rat jejunum (beta 3-receptors) (ED50 = 18 microM), but did not affect the atrial rate (beta 1) or tracheal relaxation (beta 2) at a concentration of 0.3 mM. The pA2 values for propranolol in inhibiting the isoproterenol- and AZ002-stimulated relaxation of rat jejunum were 6.27 and 6.33, respectively. Thus, AZ002 is a selective agonist for beta 3-adrenoceptor. AZ002 stimulated lipolysis (ED50 = 10 microM) and glucose uptake (ED50 = 1 microM) in rat adipocytes. In both cases, stimulation was antagonized by high concentrations of the beta-adrenoceptor antagonist propranolol, but not by the alpha-adrenoceptor antagonist phentolamine. The effect of AZ002 on glucose uptake was synergistic with that of insulin. AZ002 was also assessed in vivo by using genetically obese mice (KK/Ay strain) with hyperglycemia. Administration of AZ002 in the diet for a week decreased blood glucose and non-esterified fatty acids.

• Authors: Y Hioki, Y Itoh, A Nakajima, T Fukuroda, H Ohasi, T Kamei, M Yano
• Journal: Japanese journal of pharmacology (Jpn J Pharmacol) Vol. 69 Issue 3 Pg. 251-8 (Nov 1995) ISSN: 0021-5198 [Print] Japan
• PMID: 8699633 (Publication Type: Journal Article)

Chemical References

• AZ 002
• Glucose
• Epinephrine

Topics

• Animals
• Dose-Response Relationship, Drug
• Epinephrine (analogs & derivatives, pharmacology)
• Glucose (metabolism)
• Guinea Pigs
• Heart Atria (drug effects)
• Hypoglycemia (chemically induced)
• Jejunum (drug effects)
• Male
• Mice
• Mice, Inbred Strains
• Rats
• Rats, Sprague-Dawley
• Trachea (drug effects)