| Abstract | Spirochete diversity in acrodermatitis chronica atrophicans lesions in a closely defined central European site was compared to that in the local vector population, in human erythema migrans lesions, and in cerebrospinal fluid by amplifying and sequencing a segment of the gene of outer surface protein A directly from sampled tissues. Borrelia garinii, Borrelia afzelii, and Borrelia burgdorferi acutely infect human skin and invade internal tissues. Only B. afzelii, however, is associated with acrodermatitis chronica atrophicans lesions, persisting chronically where the skin has atrophied. |
| Authors | A Ohlenbusch, F R Matuschka, D Richter, H J Christen, R Thomssen, A Spielman, H Eiffert
(Affiliation: Abteilung Medizinische Mikrobiologie, Universitätskliniken der Georg-August-Universität Göttingen, Germany.)
|
| Journal | The Journal of infectious diseases
(J Infect Dis)
Vol. 174
Issue 2
Pg. 421-3
(Aug 1996)
ISSN: 0022-1899 UNITED STATES |
| PMID | 8699080
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Antigens, Surface
- Bacterial Outer Membrane Proteins
- Bacterial Vaccines
- Lipoproteins
- OspA protein
|
| Topics |
- Acrodermatitis
(epidemiology, etiology, microbiology)
- Animals
- Antigens, Surface
(genetics)
- Bacterial Outer Membrane Proteins
(genetics)
- Bacterial Vaccines
- Borrelia
(classification, genetics, isolation & purification)
- Borrelia Infections
(complications, epidemiology, microbiology)
- Germany
(epidemiology)
- Humans
- Lipoproteins
- Lyme Disease
(complications, epidemiology, microbiology)
- Polymerase Chain Reaction
- Sequence Analysis, DNA
- Ticks
(microbiology)
|
