Abstract | INTRODUCTION: MATERIALS AND METHODS: We analyzed changes in NO concentration in 95 consecutive patients who underwent coronary artery bypass grafting under normothermic CPB. NO was measured as nitrite plasma level (NPL) by the Griess reaction. RESULTS: In all cases a significant NPL increase 30 minutes after starting CPB and 10 minutes after CPB interruption was observed (p<0.005). No significant differences were measured 60, 120 and 240 min after CPB interruption when compared with before CPB. Three patients experienced vasoplegic syndrome and NPL values measured at 60, 120 and 240 min after CPB interruption were still significantly increased when compared with before CPB (p<0.005). CONCLUSION: NO plays a role in the CPB-related hemodynamic disorders. Use of NO synthase inhibitors could provide a better management of vasoplegic phenomenon following CPB.
|
Authors | G Speziale, G Ruvolo, B Marino |
Journal | The Journal of cardiovascular surgery
(J Cardiovasc Surg (Torino))
Vol. 37
Issue 3
Pg. 301-3
(Jun 1996)
ISSN: 0021-9509 [Print] Italy |
PMID | 8698768
(Publication Type: Journal Article)
|
Chemical References |
|
Topics |
- Cardiopulmonary Bypass
(adverse effects)
- Coronary Artery Bypass
- Heart Arrest, Induced
- Hemodynamics
(physiology)
- Humans
- Nitric Oxide
(blood, physiology)
- Postoperative Complications
(etiology)
- Syndrome
- Vascular Resistance
|