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Association between Helicobacter and gastric ulcer disease of the pars esophagea in swine.

AbstractBACKGROUND & AIMS:
Swine present spontaneously peptic ulcer in the gastric pars esophagea and are frequently colonized by a spiral bacterium that is of the same species as Helicobacter heilmannii type 1. This organism is also observed in the gastric mucosa of patients with gastric symptoms and who present with gastritis at histology. The aim of this study was to investigate the association between the presence of H. heilmannii type 1 and lesions of the pars esophagea.
METHODS:
H. heilmannii type 1 infection was investigated by mouse inoculation, urease test, and carbolfuchsin stain in 20 stomachs with ulcer, 30 stomachs with preulcer lesions, and 20 stomachs with a macroscopically normal pars esophagea.
RESULTS:
The microorganism was more frequently found in the stomachs with ulcer (100%) and in those with preulcer lesions (90%) than in stomachs with macroscopically normal pars esophagea (35%). Histological alterations were observed in the pars esophagea and in the glandular regions of bacterium-positive stomachs.
CONCLUSIONS:
It has been shown that the microorganism is strongly associated with naturally occurring ulcer and preulcer lesions of the pars esophagea of swine, which raises the possibility that the bacterium is an important factor in the pathogenesis of these lesions.
AuthorsD M Queiroz, G A Rocha, E N Mendes, S B De Moura, A M De Oliveira, D Miranda
JournalGastroenterology (Gastroenterology) Vol. 111 Issue 1 Pg. 19-27 (Jul 1996) ISSN: 0016-5085 [Print] United States
PMID8698198 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Topics
  • Animals
  • Gastric Mucosa (microbiology, pathology)
  • Helicobacter (isolation & purification)
  • Helicobacter Infections (complications, microbiology, veterinary)
  • Mice
  • Stomach (microbiology, pathology)
  • Stomach Ulcer (etiology, microbiology, pathology, veterinary)
  • Swine
  • Swine Diseases (microbiology, pathology)

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