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Comparison of oral ciprofloxacin and amoxycillin in treating infective exacerbations of bronchiectasis in Hong Kong.

Abstract
A randomised double-blind controlled clinical trial was conducted to compare oral ciprofloxacin (500 mg b.d.) and amoxycillin (1 g t.d.s.) in the treatment of infective exacerbations of bronchiectasis. The commonest organism isolated from sputum was Pseudomonas aeruginosa, which accounted for 34% of all positive sputum cultures. Other Pseudomonas species and Haemophilus influenzae, accounted for 19%, respectively. Ciprofloxacin produced better clinical response, a higher sputum to serum antibiotic level (mean of 0.65 in the ciprofloxacin group vs. 0.18 in amoxycillin group, p = 0.0001), broader spectrum of antibacterial activity and less side-effect. It was also better tolerated by patients. The findings suggest that ciprofloxacin is an effective treatment of infective exacerbations of bronchiectasis.
AuthorsT H Chan, S S Ho, C K Lai, S W Cheung, R C Chan, A F Cheng, C H Chan
JournalChemotherapy (Chemotherapy) 1996 Mar-Apr Vol. 42 Issue 2 Pg. 150-6 ISSN: 0009-3157 [Print] Switzerland
PMID8697891 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Infective Agents
  • Penicillins
  • Ciprofloxacin
  • Amoxicillin
Topics
  • Administration, Oral
  • Adult
  • Aged
  • Aged, 80 and over
  • Amoxicillin (therapeutic use)
  • Anti-Infective Agents (therapeutic use)
  • Bacterial Infections (drug therapy)
  • Bronchiectasis (drug therapy)
  • Ciprofloxacin (therapeutic use)
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Penicillins (therapeutic use)

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