Outcome of idiopathic membranoproliferative glomerulonephritis in children. Arbeitsgemeinschaft Pädiatrische Nephrologie.

Abstract

The aim of this multicentre study was to analyse the long-term outcome of idiopathic membranoproliferative glomerulonephritis (MPGN) according to histological type and to the presence of C3 nephritic factor. Fifty patients aged 2-14 years at the onset of the study were followed over 2-20 years; 26 patients had MPGN type I, 17 had type II and 7 had type III. Treatment was variable. At the last observation, 30 patients had reached terminal and four pre-terminal renal failure. The median survival probability until renal death was 15.3, 8.7 and 15.9 years for disease types I, II and III respectively (difference between MPGN types I + III versus type II: p = 0.013). The presence of an initial nephrotic syndrome was associated with a more rapid progression (p = 0.018). C3 nephritic factor was of no prognostic value. We conclude that the outcome of MPGN mainly depends on the histological type observed.

• Authors: R Schwertz, R de Jong, N Gretz, M Kirschfink, D Anders, K Schärer
• Journal: Acta paediatrica (Oslo, Norway : 1992) (Acta Paediatr) Vol. 85 Issue 3 Pg. 308-12 (Mar 1996) ISSN: 0803-5253 [Print] Norway
• PMID: 8695987 (Publication Type: Journal Article)

Chemical References

• Complement C3 Nephritic Factor

Topics

• Adolescent
• Child
• Child, Preschool
• Complement C3 Nephritic Factor (analysis)
• Disease Progression
• Female
• Glomerulonephritis, Membranoproliferative (complications, pathology, therapy)
• Humans
• Kidney (pathology)
• Kidney Failure, Chronic (etiology)
• Male
• Prognosis